Dysplastic alterations of peripheral blood (PB) and bone marrow (BM) are still fundamental for the diagnosis and classification of this group of diseases. So far, there is no single reliable biological or genetic marker for diagnosis. Introduction Myelodysplastic syndromes (MDS) are a heterogeneous group of hematopoietic stem cell (HSC) clonal diseases resulting from a sequence of acquired genetic alterations with the formation of an anomalous and genetically unstable clone or clones, with potential to evolve to acute myeloid leukemia. What examinations are needed to confirm the diagnosis of myelodysplastic syndromes? Thus, 38 studies were found and selected to answer the clinical question (. PICO system Using the PICO system, the P corresponds to patients with suspected myelodysplastic syndrome, I to the indication of examinations, and O to the outcomes (diagnosis). Part 1: Myelodysplastic Syndromes – Laboratory workup to confirm diagnosis Objective This article presents the guidelines on the examinations that are needed to confirm the diagnosis of myelodysplastic syndromes.
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